Tuesday, December 20, 2011

Stress and glutamate

An interesting review on the interaction between stress, glucocorticoids and glutamate just came out on Nature Review of Neuroscience.
The review focuses on the changes that stress induces in high order area of the CNS, but I can't help asking myself: what are the effects on the autonomic nervous system? Are similar in what is here described for the Hippocampus? In other words, does stress affect long term maintenance of "homeostasis"? I am sure that interesting results would be uncovered by such line of research.

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission:

Nature Reviews Neuroscience 13, 22 (2012).

Authors: Maurizio Popoli, Zhen Yan, Bruce S. McEwen & Gerard Sanacora

Mounting evidence suggests that acute and chronic stress, especially the stress-induced release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal cortex and the hippocampus, thereby influencing some aspects of cognitive processing. In addition, dysfunction of glutamatergic neurotransmission is increasingly considered to be a